Home Getting Started & Eligibility What's the difference between semaglutide and tirzepatide?

What's the difference between semaglutide and tirzepatide?

Last updated on Aug 03, 2026

What's the difference between semaglutide and tirzepatide?

Also asked: semaglutide vs tirzepatide, which is better, ozempic vs mounjaro, wegovy vs zepbound, should I switch Answer: Semaglutide works on one hormone receptor, GLP-1. Tirzepatide works on two, GLP-1 and GIP. In the manufacturers' trials, tirzepatide produced more average weight loss than semaglutide.

Both are once-weekly injections. Brand names: Wegovy is semaglutide for weight loss, Zepbound is tirzepatide for weight loss. Ozempic and Mounjaro are the same molecules approved for type 2 diabetes.

More average weight loss doesn't automatically mean better for you. Side effect tolerance, cost, and your history all factor in. Your provider will talk it through.

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